If your amp (and most 3Bs that I've seen do) has a stereo/mono bridging switch, then yes, but it is best to use 8Ω nominal speakers.
The bridged amplifier sees half the connected impedance, so an 8Ω speaker presents a 4Ω load to the amplifier, while a 4Ω speaker presents a 2Ω load, which is generally not recommended for these amplifiers.