I must be unqualified to use the Harmony remotes. Never owned one, but have used them occasionally at B&Bs we have visited in the past. I always seem to get them off sync, and have to figure out what I turned off or on.

maybe if I owned one it would be different.
Been using an OLD Universal leaning remote (MX-500) for years now. Along with some lesser RF20s, which work real well with the RF stations, through out the house. Basically if one want something to work, a dedicated button has to be pushed. When that MX-500 goes, I will be lost.
I would love to find a universal that acts more like a smart phone or tablet, with a touch screen but learns and controls like my old Universal one. Maybe it's already out there. And it won't be cheap.