Do you have a schematic for this amp?
If not, I suggest you get one.
The transformer goes to the rectifiers and to the PS caps. This is what makes AC to DC. The output transistors are coupled to the + & - DC voltages. If the output transistors are shorted, a very good possibility if you shorted the speaker wires, they will directly connect either the + or - voltage rail to ground. This will then cause the power supply to try to draw a large amount of current from the wall causing the fuse in the AC line to blow.
Remove the output transistors and check continuity. If you read a short, you have found part of the problem. If you do not have a schematic it will be hard to progress beyond this stage.