Actually, the classic audiophile "wisdom" is to have the source as neutral as possible and to flavor the sound with downstream gear. The rationale being what is lost earlier (i.e. lost detail) cannot be recreated later on, sort of like trying to create HD quality picture with DVD players.
Come to think of it, all of my gain stages are tubed at the moment (except for bass amp), and it's unlikely to change as it literally look a decade to reach its current state of synergistic equilibrium.
BUT if I could start over from fresh (who wouldn't!), I MUST have 2 things nailed in my system. 1) Speaker/Rooom eq/correction, and 2) speaker crossover. This is where a system is made or broken. It doesn't really matter how neutral or lovely the upstream components are if the final reproduction doesn't resemble the signal fed into it.
This means using something along the lines of: Z-system digital eq/room correction/preamp units, TACT RCS units, DEQX units, Behringer digital eq or digital x-over/eq units, dBX digital x-over, Perpetual tech P1 digital correction(if it ever releases more versions), Meridian digital solutions, OR PC software-based solutions for x-over and eq.
Something like VRS hard-drive based digital source-->digital stream to DEQX digital x-over/room correction eq (
http://www.e-speakers.com/products/deqx-new.html )-->digital stream to ICE or class D or T digital amps with digital input-->Speakers using almost full-range midrange driver augmented by supertweeter and subwoofer with NO internal crossovers.
Or, you can do it cheaper by building your own audio-only PC with software-based eq/room-correction/crossover-->DIY digital amps-->suitable speakers.
All the current "negatives" reported with digital amps can be eq'd or room-corrected out. These include the reports of "recessed midrange," "sterile highs," lean bass, etc. "Tube warmth" can be dialed in also, perhaps in frequency/time domain eq, or later with harmonic-distortion generating circuitry (let's face it, it's the lovely even-order tube distortions).