True science is not the expounding of dogma, but the logical search for truth. It does not blindly accept anything as fact, but goes about to prove what is real. Science therefore must admit to having a limit, as scientific mysteries still exist.
Yes, mankind has a need to explain the world. First we used superstitions, then religion, then science. We'd all like to have a single system of thought to cover everything.
Beyond our ability to know via science we must rely on other other systems. Leaving science requires a surrender, to admit our limits, and reliance on others. This goes against macho, independent thinking that is so American.