Welcome to AC!!!
First, take your time and audition, audition, audition!
Second, your room (size) will limit what speakers you get, so make sure you take that into consideration.
In fact, if I were you, I might budget a big chunk of your money for room correction, like TACT 2.0 or 2.2x, and some for room treatments.
The DEQX 2.6(P) can be used as a crossover, pre, dac, and room correction.
The Tact can be used as a pre-amp and a DAC, speaker correction and room correction.
I have the Selah Tanzanites and think for your size room they would be a pretty great match.
The best bang in speaker cables that I've found is the Greg Straley Reality cables..these will run you about $250 8' pair.
I think that I would try to audition a modded Squeezbox (Red Wine or Bolder) as a source..I would definately go computer as a source.
Best of luck to you...and again, it's the journey that's fun, so take your time.