Actually,  I'll set up the amps bias according to the tonal signature of the speakers....looking for the combo to have ideal:
emotions.....goosebumps
threedimensionality
non-fatiguing, natural tonality.
Of course this requires a huge amount of experience and feedback with speaker combinations.....well,  after decades and 7000 + amps made,  I guess I covered most of them.
I just cannot state emphatically over and over and over again as to how important the correct bias setting is for optimum sound quality....HUGE !!!!