My first question to you would be: Is the subwoofer circuit and the dedicated audio circuit on the same phase at the panel? If not, there is your noise generator.
Tell us more about the electrical connections and types of gear in your system.
Ground loops are the worst! Hate 'em. They can come from any connection in the system. I have seen gear that had the hot/neutral reversed internally. Plug an interconnect into it from another piece of gear that is wired correctly and you have hum issues.
Refrigerators and refrigerated air are big offenders. Stay tuned for news on this front.
Dave
I’m dealing w/ a summer outage project this wk. & working long hrs., but contractor broke off early yesterday to get some stuff fab’d in the shop. So that freed up some time for me to do some detective work & help scratch that itch that Dave started in this thread

…
Let me preface my comments by saying I will definitely get an electrician to do any extensive mods/ trouble-shooting, but I've added/ changed circuit breakers before in this house I’ve owned for last 3 yrs..
I checked outlets w/ 3 prong plug-in tester (all outlets are 3 prong) & most indicate “open ground” (orange center light bright, orange right light very dim). I assume this is normal for my house that was built in 1960 & has 2 conductor wire. There are a few outlets that are “correct” (orange center light bright, orange right light bright; bath outlets for ex.).
Circuit breaker panel inspection indicates fridge is on Line 1 phase, as is the outlet serving my subwoofer. Also on this phase is washer/ dryer.
My dedicated outlet for A/V equipment is on Line 2 phase, BUT the HVAC/ Furnace is on this phase as well (125a: 50a condenser, 50a sub-panel & 25a furnace), as is water heater.
I added an extension cord to the sub & hooked-up to A/V outlet to keep both on same phase opposite the fridge. Hum still there. I had a déjà vu moment, & remembered I had done this last year (incl. lugging the sub to another room on a different circuit)

, but then I’ve slept since then. I also had tried different cables between avr & sub, disconnected OTA antenna feed to avr, etc..
I had checked connections on sub amp/ driver before when I added No-Rez earlier this yr., & they had seemed snug enough.
So would it be good to switch the fridge circuit breaker to Line 2 phase w/ HVAC, & switch dedicated A/V outlet (incl. routing a cable in attic to sub outlet) to Line 1 phase? Both are single 20a breakers. I realize this doesn’t eliminate my specific ground loop problem, but assume it might help matters in general. Oh, A/V system details: 42" Pio plasma , Denon AVR, 6 speaker surround, Oppo blu-ray. 2.1 ch: GR Research N2x & servo sub, Virtue One. 2 int. amp & Dodd batteries w/ trickle charger (note: 2 ch added in past month. Sub hum problems known before this).
Edit: Seems like a 3rd line came in for the 125a HVAC.
I need look at again this weekend, but I sure hope so after tallying up all the breaker amperage. Also, the GE panel has 24 slots on left & 24 on right.