Kevin,
Good luck on the design. Kinda bummed that you won't be going with Hypex. As previously noted, maybe an option with just an active crossover will be attractive to us with custom Hypex amps 
Either way, looking forward to what you come up with. I have held off on the Keplers, waiting to see what was next from you. I hope you look at a full range solution also (ala Von S. VR4s).
marty
I've not done all the listening trials yet but my take on the situation is as follows:
I really like the Hypex amps for use with traditional loudspeakers. They tend to not care what kind of load is attached to them and they have tons of power. I also like their efficiency, as I'm keen on environmentally responsible devices.
I designed a PCB based upon the National Semiconductor design notes for the LM4780 several years ago. It was very good, much better than it had any right to be for the price. It also was bulletproof, with little DC offset, no nasty noises at startup/shutdown, and it really sounded pretty darn good for as easy as it was to design around. When doing some listening test with my loudspeakers and comparing it to the Hypex, the Hypex solution won by a small margin at normal listening levels. When you pushed them, the Hypex won by a larger margin. The Hypex amps (UcD400s where used in comparison so it wasn't apples-apples) are just a better solution for a wider range of high-end loudspeakers.
I've also used that little LM4780 amp at a couple audiophile events. In one case, it replaced a well respected amp that was >$3K and almost everyone thought it sounded as good, if not better than the expensive amplifier. Of course that was a limited trial, in one situation with one set of loudspeakers.
The LM3886 (the LM4780 is two LM3886s in one package) as far as I'm concerned, is a high-end solution when used within the context of their design limits and designed right. They don't drive difficult loads as well as the Hypex amp. The high-power solutions require specialized care for heat removal and they should never be operated into their clipping-protection mode. When kept within those parameters, they are an excellent solution and they are very difficult to differentiate from other well executed designs. Certainly you are at the point of serious diminishing returns when you implement them driving an appropriate load.
In that context, they are actually an ideal solution for active designs whereby they are only called upon to drive individual drivers. In the tweeter the amplifier is only called upon mWatts of power and having separate amplifiers used on the midwoofer (bridged they deliver about 100-120W, more peak) you effectively improve the amount of system power. I'm using approx. 150-180W per speaker active which doesn't directly correspond to the same watts driving the passive design. It is hard to do a fair comparison but you could use a 1.2-1.5 multiplier and not be too far out of line.