Sort of my original question for Danny as well, but then I went with the 2X and then made the mini-towers left and right for when I go music only (and for that purpose they verily do shine).
The Neo-2 are, well, real nice, especially with a Servo Sub. If I were to do it again I would go with a complete "sealed" system with a servo. I would still probably go with the 2Xs up front.
But I'm thinking about the Neo-1s for my office...maybe, but I'll probably go ported since there's no sub.
And from the Random thoughts page: I'm pretty sure that the THX desired crossover point is 80HZ, and so, you can certainly go smaller. I think I've got my system crossing over at 40 right now. Yep, lovin' me some Gr-Research Neo-2X mini-towers..