Another scientist here (biologist).
Good sense and healthy skepticism are darned useful; deriding others, not so much.
Provided there is a plausible mechanism for something being proposed, I consider it worth considering. The guy on the video went from an observed pattern (hearing differences in blind tests) to a mechanistic explanation (microphonics within the component); nice work, I think, explaining the basis for the pattern others have observed for some time and could not previously explain.
So when someone is skeptical about the benefit of better cables or break-in, I appreciate their position; it really doesn't seem all that plausible. And if they have a low-resolution rig, then any improvements might truly be trivial or even zero. But as the quality of the gear increases, so does the ease with which we can detect these changes.
Personally, I have experienced sonic changes in components as they break-in that I am pretty darned sure are not artifacts of psychoacoustics. In a recent case, it was a friend's gear, so I got to hear it at roughly 100 hour intervals (all else remained unchanged). On the first visit, there was quite a bit of glare--I was worried about this new amp. These days no more glare. I have no mechanistic explanation, but I suspect there is one waiting to be unraveled.