Sure.... and you are right, there is no reason it couldn't be used IB. My statement, if I remember right, was aimed at someone asking about the Maelstrom-X in an infinite baffle. The only basis for my statement was founded upon the cost per unit output in that situation. For someone buying the Sicko-21", the value is probably not at the top of their priority list.
I still think that if you are doing IBs, you should consider drivers firing in opposing manner. In other words, you would want at least TWO Sicko-21"s mounted in a baffle firing at or away from each other. You will also find, that as the driver size increases the baffle opening needs to increase also. For those reasons I normally recommend people keep their driver size limited to a 15". Four 15"s mounted in a baffle allows you to keep the baffle opening small, it fits between stud spaces and you would be better off in terms of in-room response by having multiple four driver arrays of DPL-15s rather than a single Sicko-21" manifold.