The answer to this will most likely put this thread into "the lab" I guess. (We'll see if DU see this and agree)

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Cryogenics - When discussing heat treatment, cryogenic treatment must also be included. One may wonder why, since heat treatment is done with extremely high temperatures, and cryogenic treatment is done with extremely low temperatures reaching minus 300° F. Because of this, we contacted Bob Reed, Motorsports Division Manager for the past 13 years at 300 Below, Inc. in Decatur, IL. "Cryogenic treatment does not take the place of heat treatment, rather, it completes what the heat treater started," explains Reed.
"When heat treating, the temperature is increased to the proper 'high' temperature for the type of metal being treated. At the correct time, the parts being heat-treated are put in 'the quench,' at which time the temperature begins to decrease. It is during the quench that the improvement actually takes place. Parts become cooler and cooler, and better and better. The heat tr eater considers the treatment completed when the temperature of the parts reach room temperature.
Heat treatment is great, but there is nothing magical about room temperature, says Reed. It is at this time that the heat treated parts can be cryogenically treated, because when cryogenic treatment is properly performed, cryogenic treatment begins at room temperature, and through computer-control drops at the rate of one degree per minute until the temperature reaches 300° F. Small drill bits, sewing machine needles and guitar strings can be cryogenically treated at the same time as big engine blocks, gears, pumps, etc., but the treatment time must be based on the biggest, thickest cross-section. In other words, cryogenic treatment is not a surface treatment. The entire thickness is treated and receives the benefit which is normally improved performance, reduced wear and breakage, longer between rebuilds or replacement, reduced costs, and (hopefully) a more successful motorsports season.
Cryo processing also is used to stabilize aluminum and other non-ferrous metals.
Cryogenic tempering conditions the aluminum so that large temperature variations can be tolerated with minimal distortion.(And that was the punch line here folks!!!)
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And a note from me...
Say you while assembling the tube also cryo it just after pulling it to -8 Torr ...
That would get you a best possible tube... eh?

So ... did that answer your question?
And we could go on!
No, just reddish won't destroy the cryo treatment, as cryo is not so special after all, just a finnished heat treatment...
But now you guys should be in no doubt that cryo do work!!!
Also, what parts of the tube that actually emit or recieve electrons is also a part in determining how succesfull a cryo treatment will be.
Of course, if the tube starts to melt... Actually, you know that certain elements of a tube have coatings, some use graphite elements, some are gasfilled and so on. A generic answer to your question is difficult I guess you could say..
But the general rule is this:
If the metal undergoes a phase change in the metal itself every time it heats up, then the cryo treatment is destroyed, otherwise not.
Imperial