it would be better to do it at a higher signal level rather than a lower one
But do we prefer to switch the higher voltage or the higher current? That's what I am researching right now. So far I have been led to the hermetically sealed gas-filled telecom relays. They were designed for this type of application. Also looked at reed relays. The advantage of a relay over a switch is the gas tight seal, plus you can bounce the contacts on each power up sequence, keeping them clean. Must be very careful regarding dissimilar metals and photoelectric and chemical processes at these signal levels.
My paper design (at the moment) has cartridge loading on the secondary,
prior to the relay. So signal switched by relay is the higher voltage and carries very little current, being independent of cartridge loading.
jh