There is difference in wires -
definitely.
I have tube amps now. Thinking nothing of it, I strapped a 6' pair of Kimber 4TC to them when I got them and hooked them up to the speakers. They sounded just fine with a number of (SS) amps I've had in the past 4-5 years.
Recently I read capacitance is a naughty

thing for tube amps...the
less the better for them. The Kimbers are among the highest capacitance in the biz per foot...even tho I'm using 6' sections, it might be a lot more capacitance than my tube amps are happy with. Hmmm, says I, maybe it's time for a cable swap

So, I swapped out some 16ga lamp cord with it this weekend. Kabloowey!! - a naturalness to the music kinda' bloomed (I knew it in a few notes only) and the slight trace of transformer hum - evident all the while with the Kimbers in place if you stood close - was now gone. The Kimbers were creating some low grade oscillation to my amps as it turned out.
So, in this case, 16ga lamp cord was better than a well-respected wire from Kimber. Most of you with solid state output amps won't likely ever notice the difference...but it was clear as day to me with my tube amps.
Tho it's overall preferred - things aren't quite as crystal clear as before with the Kimbers in place. There may well be reason for highly pure copper over the standard garbage in the lamp cord...it sounds better
all other things being equal.
This 'synergy' term is really overused a bit. It's pretty clear to me it's one part subjective sound and one part electrical reality that makes a wire or component work in
your listening area. Unfortunately, except for the electrical reality, the subjective part requires trail and error to find something that is pleasant to your
specific ears.
That takes years sometimes. That's why we all band here at at AC and grouse about it
