It might be difficult to find other drivers of that size that will fit. This Fostex
might work:
http://www.madisound.com/cgi-bin/index.cgi?cart_id=4363441.24938&pid=331Be careful though, the MDF doesn't take kindly to screwing\rescrewing and the holes are VERY close to the cutout. My pair are a bit stripped out on one side thanks to my curiosity of looking at the inside. Whoops!
Personally I think upper treble is where the drivers are lacking. But they take tone controls very well. Although my NAD 3225PE has about the only really nice sounding tone controls I've ever heard, it's nice and subtle. I never got to hear the 4.0s but my guess is that you might be giving up the single driver sound. It's hard to quanitify but these small drivers have a very coherent sound. It all seems to hang together.
Goosing the treble a bit and running a sub crossed at 60Hz may yield good results. How are they set up in your room? I've found that their small size combined with a wide spread of about 9-10' gives really good imaging. But there's no doubt that they have a certain coloration. Ed's Horn would be the next speaker I would try in the small single driver format but of course that's a big 'ol box. Er, little 'ol box maybe. Quite a different look.