First, they're probably going to sound pretty darn similar. They use the same midrange and bass drivers. The midrange drivers are sealed in both designs. The bass drivers are ported and tuned to 27-30hz in both designs. Similar, similar, and similar.
Second, you should probably do some research on whether you like ribbon sound or fabric dome sound. With the midrange and bass drivers being the same, the largest difference between the voice of the two speakers will be in the treble.
Third, the RA8 is rear ported and uses side firing drivers. This is an issue for some HT folks that like to place speakers against the rear wall and near side walls. Many of my HT enthusiast friends will not buy rear ported or side firing designs for this reason. Others like the bass and midbass rise they can obtain these ways...
Fourth, I wouldn't try to just "turn a speaker on its side" and make it a center. If you want a center, buy an Exodus LCR or a raw HT2, two speaker -designed- for LCR use.
Fifth, the RA8 includes really high quality crossover parts. If you're into that, great. If you think they are a waste of money for the small sonic increase, bad.
Sixth, Raw's finishing work is amazing. You'll have to price similar work for the 2641.
Seventh, the MTM configuration will control vertical dispersion some. If you have a reflective low ceiling or reflective floor, this is probably a good thing. If you don't, it probably won't matter.
Anyway, both are great speakers. They'll sound pretty similar. -You- gotta decide which design better fits your needs. I've at least brought up some considerations for you.