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Of course PCBs are virtually required for solid state circuits because the components are designed to be used with them (there are exceptions)....
I doubt there is any sound difference. Point to point wiring is has to be much more labor intensive, however, resulting in a more expensive product - all other things being equal.
Wouldn't the main downside for pcb be applicable only if using the printed wire traces? I've seen many applications where the pcb is used as a mounting board, and individual wires are soldered between parts. Wouldn't this method be superior over using the circuit traces?
Circuit boards are generally poor for analog signal propagation, except for short paths, due to their high dielectric constant. They are acceptable for most digital applications, but not optimal for this either. They are convenient for attaching integrated circuits and transistors, so called "active" elements, and interconnecting these over short paths using "traces" or "nets". Ground planes or large copper fill areas are typically used for completing the circuits between active elements. Point-to-point wiring harnesses are generally superior
I have no innate opinion of this, I will merely weigh in with Steve Nugent/Empirical Audio on the subject from his white paper (on his website): As this comes from the man partly responsible for bringing to us the Pentium 2 while at Intel, it's worthy of strong consideration
If you can hear the dielectric effects over all that extra noise then I'll lick your boots.