Various tube preamps have remote controls. The Modwright does. An inexpensive tuner can easily be added.
That said, the noise floor of the components will be the most visible element. The volume control of your preamp will likely get twitchy, with very small increments translating to big swings. Amps or preamps can be tweaked to reduce/eliminate this effect.
The speakers as a whole are not tonally picky. They will stamp their sound on whatever you pair them with. This is not to say the electronics won't shine through, but the strengths of the speakers are inherent, not depending on some magical combination to bring them out.
The supertweeter is not agressive, merely adding some sparkle to the top end. I think a system would have to be annoyingly bright before it would get annoying on the Druids.
For amps, Nelson Pass' new, classic truism of the First Watt could never be truer. With speakers this sensitive, everything you listen to will be entirely within one watt of power. This does not necessitate a small amp, however it does demand that to excel, the amp must be exceedingly good at very low power. Since most large amps are not designed around this parameter, I would guess most larger amps would communicate somewhat reduced microdynamics and shading. I have not tried these with big amps though, so this is mere speculation.
They are not clinical or sterile. Tube-o-philes should Love these critters, though I could imagine that a heavily tubed system could be too much with these speakers.
That's about all I've got. I happen to love the synergy I've got going now and have no upgradeitis. I'll keep playing around but it's all gravy from here.