As I mentioned previously, I prefer the sound of the F5M to the F5. While it uses the same basic topology, there are enough differences in the circuit to change the way it sounds.
The current-limiting and temperature compensation circuits are eliminated. This current limiting circuit protects the amp if the outputs are shorted, but I think it has some minor adverse sonic effects by causing some dynamic compression. The temperature compensation circuit adds thermistors in the bias circuit which I am sure are not as clean sounding as high quality resistors. Removing them increases the time to fully warm up (and increases the amount of time it takes to set the bias when you are powering up for the first time), but I'm willing to accept this to get the best SQ. The F5M also uses different output devices which shift the distortion profile to be 2nd order dominant. And finally, the F5M has a bit less overall negative feedback.
The result of all these changes is an amp that sounds cleaner and more dynamic, with an improved soundstage width and depth.
I'd like to build an M2X at some point. That looks like an interesting amp.