Duke will have to pardon me on his forum, but I see no reason not to use your mains full range and use subs to smooth the response and increase output/headroom.
The benefit of the minidsp is it also allows delay (along with EQ, phase, etc), so that the added subs can be placed in various spatial positions that work best for whatever one is hoping to accomplish.
The key of course, mains that are as capable at LF as subs, in extension, power, inaudible levels of distortion, etc.
One of the setups mentioned in the paper are 5 fullrange speakers (no "subs").
cheers,
AJ