I really believe there are things where effort goes a long way in making a better sound, but there is also so much 'audio voodoo' out there, that it gets really hard to decide where to really focus one's efforts (there's also a matter of budget, of course!).
But, for instance, this whole notion that a $300 USB cable is better somehow than a $3 cable, because by reducing the Jitter the DAC will have less effort in translating the audio, is, IMHO, nonsense. Either the DAC gets the signal, or it doesn't. Yes, it can get noisy signal, in which case it needs to work harder to 'decipher' the underlying code, sure... but once it does, its just 1 and 0s. They should sound the same!
So I understand if, AFTER an AMP, the powered signal needs to go through a fuse, yes, that may affect things. But if in the 1980s they figured out that by putting the fuse before the amp signal, as tells the story in your link, any manufacturer not doing that is simply not doing things right. And if, after that, they are relying on $0.50 fuses, then we should not buy from that company. If that is not the case, then changing the fuse should have as little effect as possible!
Lets try analogies, since you are using them. If you buy a $10.000 car, maybe stock tires may work. But if you buy a $80.000 Porsche, do you think it would be wise for them to ship with under-rated tires? No, they would ship it middle to high-end tires. If NuPrime values the quality of their sound (obviously they do!), are you telling me that the sound can get twice as much 'transparency' or 'openness' by changing something as silly as a Fuse? Then someone at the factory should get fired, IMHO.
Then there are those that would charge you a kidney and a lounge for what costs them $3 to manufacture, just because it "audiophile grade". Then if we buy that, we are the morons!
Have you done A-B tests? Blind tests? Or is this one of those: "I listened for a hundred hours with setup A, then changed to setup B, and after a 100 hours, I kept going back to wanting setup A". Because if it is not side by side, the ears can hear whatever they want. After 10 hours, a $30 Bluetooth speaker probably sounds to you the same as your $30.000 speakers with $20.000 amps. So can anyone share facts before spending $300 o a fuse?
This is really the low point of being an Audiophile, and a part I don't enjoy one bit. To have to be 24/7 'on guard' to filter the utter nonsense from the actual facts.