Room that I used the speakers most: 12 x 13 x 8 plus an extension to the bathroom on one side of the narrow wall. I did test some of them outside in the much larger living room.
As to amps, agree that the 22 watt 845 based tube amps sounds low. I also did test the Vinnie Rossi LIO with the LS50. The LIO has been raved about with the LS50 though the wattage is low. So I do feel that I've given the LS50 its due. As to placement, I have stands for the LS50 and moved them around the room from the wall for best placement. All my speakers are about 30-36" from the rear wall for the sense of depth/soundstage.
Hope this helps.