You can expect LIO MOSFET AMP to work well with a
wide variety of speakers, as long as you are not
asking for it to output more power than it can.
Speakers with impedance dips down to 2-ohms will still be ok and should sound fine - again, until you are trying to
push out more power than the output stage can deliver. LIO's MOSFET AMP has low output impedance (< 0.1 ohm)
and a very high current power supply - so it may trick you into thinking there are more ponies under the hood.
When I visted ALO Audio in Portland last month, we connected LIO to the massive Gamut RS9's (89dB, 4-ohm, dips to 3.2 ohm)
and they sounded stunningly good! We were easily breaking 90dB peaks and feeling the punch.
I also have a customer who was using a much more power amp (> 200wpc) into Vandersteen 3A's, and he
decided to try the LIO's MOSFET Amp and he was surprised how good it sounds and allowed him to
play at the same listening levels that he normally does.
At the other extreme, I expect Omega's and other single-driver, high efficiency types to work great with LIO.
LIO sounds mighty impressive with Harbeth 40.1s and I have been using my pair in a near field arrangement and
get amazing results!
DARKO tested LIO with KEF LS50s and Zu Soul MK2's (naturally, the Zu's will allow you to play louder for rocking out
at higher dB's).
Other reviews are in the works, and they have the LIO MOSFET AMP to report about.

I hope other LIO owners will chime in and post what they are using for speakers. Thanks for all your posts so far!
Vinnie