First, you cannot beat Salk speakers in
any setup.
My take, as in my previous post, is that you can put a good speaker in a large room, and it will sound better than a crappy (read lower performing) speaker in that room. You can put a good speaker in a small room, and it will sound better than a crappy speaker. All optimal acoustics aside (few of any of us have the "perfect" acoustical room), if you buy large, great speakers, they can sound better than any lesser speakers, irrelevant of size. (We DO have volume knobs if you're worried about ... 'overwhelming the room'.

) If you add good acoustic elements, of course
any speaker will sound better.
My advice...get the best speaker you can afford. I definitely agree with Ratso and Jonnyfive on this.
That's my story and I'm stickin' to it.
Best of luck with your decision...but by all means, stick with something from Murphy/Salk.