Depending on your budget of course but here it goes, shooting half blind

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- amplification/speakers matching is often underestimated and it is probably one of the most important steps in achieving great sound. With that in mind, I would start there.
- Wyred4Sound is great and easy recommendation. Which model to get thought will depend on your needs and features which are important to you. If you do not need remote control and volume options (I think you will be better off with either buffer or dedicated preamp) go with W4S 1 and add something like Dodd tube buffer with remote control for tube "flavor" and excellent sound quality.
For source component I would go with PC (Win or Mac).
Just my 2c