Kerfing works very well. I was doing this about 10 years ago when custom designing and building speakers. If using MDF, the key is not to scratch or mar the outer service if you want to paint the cabinet. Once you break that outer skin, it's a pain in the ass to get a smooth, paintable service back. If using Veneer, this is not as much of a problem.
One of my secrets........ scoop up some of the MDF sawdust off the floor. When you are ready to fill the 'cuts', mix the sawdust with some wood glue. This will provide a stronger bond and not waste as much glue. Think about it. What is MDF anyway.
I have also used this technique with veneered plywood as the outer veneer coat holds things together and keeps the integrity of the structure. Once internal bracing is installed, you are good to go.
I have also tried other techniques as mentioned in this thread such as cutting special shaped "frames" out of MDF and then using multiple layers of thinner material to build up the skin. I once built a large speaker that used 10 layers of 1/8" outer skin material. This produced an extremely rigid enclosure.
Imagination is all that is needed to come up with a design that fits your needs. Don't spend to much time asking yourself "is this a proper method" because it doesn't matter. If it works for you, that's all that counts. Be unique. You will have more pride in the finished product.
