Thanks for the reply, Scott.....To give you a specific example, I currently run an Outlaw Audio 950 pre/pro. For the money, it's quite good. But for the same money I could have something like the Anthem TLP-1. It's basically a 2-channel preamp/tuner that incorporates low pass/high pass filters for use of monitor speakers and 1 or 2 subwoofers. (I've just always preferred the sound of a monitor/sub combination over a floorstander.) So basically, assuming I get a nice amp to mate with my mains, can I get the same 2-channel performance out of a pre/pro as I could by spending the same amt on just a stereo preamp? I've had several different combinations of speakers and components over the past five years or so, and what I"ve found is that it's much easier to find satisfaction with HT than it is with 2-channel audio. That's what I really want to focus on this time, so I really want to be smart about where I spend my money.
The biggest effect on sound is speakers. I'm going to assume you have something you like there, so I won't get to try to convince you of the merits of buying speakers from me.

That aside, if you are looking for better sound, it's almost always found by moving up in speakers.
Barring that, if you are running Outlaw electronics, yes there are improvements to be made, but they might not be huge, and the cost starts to go up pretty quickly. Outlaw seems to have a nice price point.
After speakers, next biggest effect is pre/pro and amp. Spend the money on a good stereo amp or monoblocks, something you can keep for years. Again, Outlaw has a decent reputation; and you haven't mentioned a budget (or what you have for speakers) so I don't know if it's worth moving up in amps. If you have bloody excellent speakers, it probably is.
I can't wholeheartedly tell you to abandon a 5.1 pre/pro for a stereo preamp. In "bypass" mode, which your pre/pro has, the signal is passed straight through with a minimum of muss and fuss, and it's probably being kept fairly clean. Shame on Outlaw if it isn't. Pouring a lot into a stereo-only preamp might not gain you much over that. A lot depends on how well your speakers resolve.
You need to set your budget. I can recommend an absolutely stunningly
wonderful system for 2 channel, with awe-inspiring 5.1 capability, for about $25,000. If you're looking to spend $3,000, that doesn't help much.
(And I'll say this once because everyone here expects it of me - treating the room is 9 times out of 10 the biggest improvement you can get. And sometimes it doesn't cost very much. If the room is untreated and you really want to kick up your rig's performance, start there. If that's an option for you, look at my website, I won't go into it here.)