Ah, these x00R amps spoil the tubes, they last forever... but once the idea of a tube gone bad gets into my head, some swapping usually happens. Even if not permanent, for experimentation at least.
Fatigued tubes sound like...like...like they're running out of gas?

If you're not comfortable or eager to replace the tubes, you should probably call Frank. There is a version of the 400/600R that has a bit of high voltage somewhere near the tubes. It is supposed to be a user-replaceable part afaik, but the user needs to be aware of how to do these things safely. If you have done it once or twice, then it takes about five minutes.
If you ARE comfy with tube swapping, well, it might be worth it just to be able to relax and confirm that the new tubes sound just like the old ones. You can then relegate the old ones to backup status and be comfortable knowing that they are a trusted reference.