The box shape itself is not critical for WinISD which is only considering the volume in its simulation. But in reality, box shape affects mechanical box resonance, internal pressure distribution, internal acoustic resonance, baffle step response, edge diffraction, which all affect tone quality. No reason not to make it any shape you want, it will simulate the same, but consider the other factors in your shape choice.
It sounds like a nice project you're starting. Is the bass sealed or ported? If sealed, you might want to boost the bass which would require a driver than can handle the additional power, and more box reinforcement against the higher pressures.
The Audax looks like a nice sounding driver. The only caution is in using it down to 150Hz as you plan to. Its flat surround limits the excursion, which makes it roll off at higher freq, -10 at 150.