I am experiencing a low-level "hiss/buzz" in my speakers. Someone suggested I measure the DC offset at the speaker terminals. I did and I was getting a fluctuating reading from about -30 mV to +50 to 60 mV DC. This reading was taken with my Clarinet on and my amp on. When I switched the Clarinet off, the reading was very low, about 1 mV DC. Does anyone know if this level of DC is capable of producing the slight buzz? From my reading, it appears a DC offset of >100 mV is bad, but I don't fully understand this. Any thoughts appreciated!! 
Hello,
First off, are you using a tube amp? If so, then you should not measure any DC at the output terminals because the Output transformer should not pass DC.
I will do what Dan suggested.
Let me add that if it was me, I will disconnect the preamp to the amp, leave the amp connected to the speakers, short the input of the amp if possible. Turn the amp On, any noise, instantaneously or after say 5 minutes? No, then it has to be the preamp. Also measure the AC in mV from the speaker output terminals( + of the meter leads to 16/8/4 ohm tap, minus on the GND terminal) and write it down. This is the output coming from the amp at idle with no input.
Heres my take.
For the preamp, lets take one channel at a time, you can see that the output of the Clarinet is cap coupled (C303)...

... it should not pass any DC. With the preamp ON and disconnected to the amp, measure the DC voltage from the top of R312 to GND (same as the output pin of the RCA), there should be zero or very close to zero. If it is large (I hope not close to the 145 DC minus the voltage drop at R311 on the cathode of V301A) then maybe your cap C303 is shorted or leaking. Do the same for the other channel.
If both channels measures close to or at zero volts DC, then, the buzz you are hearing might not be coming from DC but might be AC . Is it really a buzz or a hum? If it is a hum, it could be a ground loop.
With both preamp, amp Off, connect the preamp output to the amp, and amp to speakers. Turn On preamp first, wait a couple of minutes, then turn On the amp. If the noise you are referring to still exist, measure it with AC on the speaker terminals and compare it to the recorded reading you have. You can tell how much is the difference and if so, can use it to trace it on the amp preamp circuit path.
Note: Do not connect/disconnect input signal wires or speaker terminal wires when power is On on the amp.
Goodluck!