Depends on your definition of profound.
Years ago, I swapped an Alphason HR-100/Dynavector 17D from a CJ Walker to a VPI HW19 and eventually to a Sota Star. There were differences. The Walker didn't have the bass impact of the VPI, nor the depth of field. The Sota was a little quieter, but didn't have the energy of the VPI.
The differences were audible, and of a greater magnitude than swapping cables.