Yes, you can drill holes just about anywhere on the board. Just pay attention that you don't wipe out any traces. Or worse, use a metal standoff/nut that shorts a few together.
The circuit boards machine very nicely. You can drill, mill, and file. I put in maybe a dozen holes on the CHIME board in the GOLD unit. I've cut the battery wings off a BUGLE (great for those spacially limited). Milled out some ground plane for clearance on the OBOE, etc.
jh