In general, I prefer avoiding any DAC and ADC steps that can be avoided. At a certain level of engineering, they should be inaudible, but why do it if not necessary? Not all devices will be transparent. So . . . I would start with the digital connection.
You may know this already, the miniDSP SHD series has miniDSP's latest technology, a built-in streamer, and Dirac Live. It's the miniDSP device I'd choose if a maximum of two channels in, four channels out is sufficient (two mains, two subs). Or do you have the miniDSP device already?