With the Three series, a slight change in toe in or toe out of even one inch, can create huge changes in the mid/treble crossover range -- three to four db. This can cause the speaker to become strident, especially on female vocals.
I find it essential to measure the distance of the speaker and of toe in to an exact measure. I do it by anchoring a piece of string to the back of my chair behind where my head would go (I clip the string to a heavy tape measure). I then align the inside edges of both speakers to be exact same distance per the string. I then adjust it so the tweets are about a half inch closer to me than the woofer, and that the two woofers are the same distance from me. This leads to a smooth crossover with no peak in the 2-4khz area,and matches up with the current manufacturers recommendation graphic (the tweet is no exactly straight on to my ear as per their picture) If speaker volume isn't matched perfectly, I then move one up or back slightly to balance everything, keeping the relationship of tweet and bass the same.
Another cool effect is the roughly 45degree angle with tweets in. This also has extremely smooth treble. It also activates the lateral bass of the room (granted not always needed) and it seems to stimulate the upper Mids. It is a bit veiled sounding, but the imaging is absolutely exact. The other benefit of the 45 degree is it eliminates disturbing side wall reflections, as it puts them in the null, again even further improving imaging.
Tweets out loses a bit of "palpability" on center vocals imo, but gains a richer tone which is absolutely gorgeous. I am not exactly sure why. It does not necessarily result in wider imaging, indeed, center left or center right images can actually move in to the center and back and away from the speakers. Bass is better or worse depending upon the room positioning, but often gets weaker with bass panels in away from the SW.
One other thing on toe in. Some piano and flute and jazz guitar can "ring" or sound hashy if the tweets are off compared to the Mids. Once you hear it, it can drive you crazy, as you will hear the tweeter. Again, this can be fixed via the degree of toe in, and the troubling musical selections can be used to demo it is set up right.
My thoughts.