Short answer: Yes. I have a preamp hooked into my Sig 15, and it works fine.
Long answer: Vinnie knows more about the ins and outs of the electronics, so I defer to whatever he has to say in the matter.
After some experimenting, I find it best to turn the volume (nearly) all the way up on the preamp and then adjust the Sig 15 to reach the desired output level. Others do the opposite. Experiment and see what works best for you.
Hi JeffV,
Thanks for your response.
LAmitchell - ideally, if you are using a preamp you want to have the Sig 15 converted to a power amp (no volume control or input select switch in the signal path). This will give you the cleanest signal path from preamp to the Sig 15 tube stage, and your preamp would see a higher input impedance.
However - you can still use a preamp connected to the Sig 15 Integrated. I would start with the Sig 15 volume set to MAX and then use the preamp volume control. If you have too much gain (the preamp volume control gets the music loud too early on the volume control), then reduce the volume setting on the Sig 15 until you have a nice, usable range of control on your preamp, and the least amount of noise and distortion from your preamp. There is no magic setting - you just have to play with it and you'll find what works best for you.
Yes - you can do what JeffV does (set the preamp to a fixed volume, and adjust the volume via the Sig 15). That also works, but I prefer to do it the way I mentioned above, but JeffV is not wrong for doing this. The best way is the way that sounds best to you.

Good question, BTW!
Vinnie