My issue with the "wide" layout is that it places you up fairly close to the rear wall, yes, it can be treated but still don't like being too close if it's avoidable.
With regards to the subs, stereo dual towers will easily fill that space but, as Mike mentions, , you will be working each woofer in a pair of triples less which equates to faster settling times, less distortion, and beter bass. IN a room that size, you wouldn't be working a dual setup very hard so not sure how much difference there would be..... now that being said, when I had the triples in my room , we did feel they were bettter, just a bit clearner and a bit "punchier"...... I currently run the Super 7's which have the duals built in, no issues whatsoever in my room.... even with the 95 +/- Super 7s, the amps are not being pushed, tons of headroom left.
jay