You can go for a flat measured response but in psycho-acoutics it's generally recognized that a 'house curve' sounds best to most people. That's a slope where the bass is the highest and there's a (very) gradual roll off as you get higher in frequency.
Re: bass modes, OB's are definitely better than box speakers but even OB is not perfect. There's generally 1 bad mode that's still excited even with an OB. It would be nice if the powered X series amps had an EQ built in that would let you knock that down at the amp level. I know in my room I have a really bad 50hz mode and a moderately bad mode at 100hz. Since I'm digital only up there, and I use Roon as my only source, I just use the (good quality) EQ that's built in to Roon.
I notice after I deal with these humps, the speaker naturally has a very nice 'room curve' without me having to apply any other major EQ to it. Very nice!