If you're asking regarding the open baffle woofers that most are configuring with an opposed facing in an H-frame baffle, mounting them as you describe with an open back an no change otherwise in overall dimensions gives you:
- a cardioid shaped dispersion pattern (more output to the front than back, nulls not directly to the sides) different than the equal front-back output with nulls directly at the sides in the h-frame design, also causing changes in output with the change from an H-frame to a U-frame
- additional challenges in dealing with cabinet resonances as the comparative size of the unbraced side panels doubles in size
- without the drivers firing opposite each other, maybe some additional cabinet/baffle vibrations as the drivers would no longer be firing equally and opposing to reduce/deaden/negate these vibrations
In short, a completely different speaker. Not necessarily better or worse, but a different tool for the job depending on what the rest of your system/room is going for. I can't remember where I found it (if you search for old threads discussing U-frame baffles you may find it as I think I linked to it from here on AC) but I read a short essay a while back that neatly explained the basic points.