I set up my Royal Virtuosos with the tweeter on the inside! OH MY GOD!!! I can't believe how much better it sounds. We're not talking subtle here, folks. This is a huge difference. I have a very small listening room (11 x 13) and I've been somewhat bugged by a lack of focus in the imagining. In every other respect, I love the sound of the system. But with this change, I've got it all. I know you're not supposed to do this, but what can I say? It sounds soooo much better. I'm getting razor sharp focus now and the soundsage is even wider than it was before. Chalk one up for experimentation!
Maybe this puts the tweeters farther from the side walls so there's less side reflections. I really don't know and I don't care because the sound is so awesome now I can't believe it. If you have a small room and you've not been getting the focus and palpability you want, try reversing the speakers.