I am sure this kind of paint and working on MDF with its own finishing challenges won't be easy, but i wanna try!
MDF can be painted easily with automotive paint, but you will have multiple layers of primer on there. Wood loves to soak up whatever material is painted. First off, SAFETY! This stuff will kill you if you don't pay attention to safety. Cartridge respirator, spray suit and gloves are mandatory. If your neighbors think you're cooking meth then you're good. But first, sand the mdf with 220 grit and prime with 3 coats of primer. Let that sit a few days, sand with 320 and prime again. Wait a few more days, sand with 400, then 600, wipe down with wax and grease remover and then spray your basecoat, then clearcoat. This can be done in aerosol if you don't have access to a spray gun and compressor. All in, factor probably $150 for the good stuff in aerosol. Go see your local automotive paint shop. Any questions on materials or process, send me a pm and I'll walk you through it. It's nice to see some speakers get the full paint treatment.