It appears Sprycel is a Bcr-Abl tyrosine kinase inhibitor. It is a second-generation drug relative to Gleevec and was developed for individuals whose CML was resistant to Gleevec.
Ten years ago I was diagnosed with polycythemia vera, a distantly related myeloproliferative illness. I was tested and I am positive for the Jak2 tyrosine kinase mutation. After failing an 18 month trial of recombinant interferon I was placed on hydroxyurea, a drug discovered in the late 1800's with a side effect profile that is not nearly as problematic as the interferon and available at dirt cheap generic prices.
I am here to tell you to do TONS of research on the internet and learn to tell the difference between reliable and reputable information versus hearsay and rumor. Do not assume your physician will be aware of every single piece of information relating to your disease since CML is one of the "orphan" leukemias and is not common. I have run into several hematology/oncology specialists who were not at all well-versed in polycythemia, the patients who convert to acute myeloid leukemia, or side effects of medications they prescribe. You alone are your own best friend.
Do your research, ask questions, and don't be afraid to change physicians if you don't feel you are being well cared for!
