I've found, that it all depends,
If your using your subs for only the bottom octave (or so)...20hz-40hz, then mono, or stereo subs has little, to no effect on sound.
If you are crossing over at higher freq's than these...stereo bass gets the nod over mono bass (at least to my ear).
One other thing. Using the preamp outs, and depending on "your" system, may offer more flexibility of choice...ie, outboard crossovers, filter types, crossover points, bass EQ, ect...ect.
In a perfect world, none of this would matter, all subs, in all rooms would blend perfectly.
Dave