6" of airspace behind the speaker? That's about as close as I would recommend. But further will be better if possible.
And you want your subs to come in below the roll off point, closer to 50Hz for a sealed speaker otherwise youll get a big spike (or hole depending on phase) in output throughout the midbass, where they overalap.
If you have the speakers ported you'll want the subs set to about 35-40Hz.