For power cables, we recommend the B24 for source gear like a DAC or phono stage, as that's where the filtering of the power cables will make the most difference, then using the B16 for the rest of the gear like preamp & power amp, as there's less benefit the further down the chain you go.
For speaker cables, the 24 strand cable is more beneficial for longer runs or speakers that require lots of current/power. (eg: Magnepans and some Tekton speakers)
For shorter runs (less than 10 feet), smaller or more efficient speakers, you can easily get away with the 16-strand cables.