Why not ask Bruno on DIY Audio? I don't recall the reasons why, but there were no issues with using the speaker level connection for my Class D Audio (the company) amp kit.
At least for REL subs, there are problems connecting with certain types of class D and speaker level sub inputs. REL makes a special cable for these I believe.
Anyway, I wouldn't ask us fools, but instead ask the sub and amp manufacturers themselves. Would be terrible to get bad advice from someone on a forum that leads to things getting fried.