How much extra work do you want to add? The more programmable the remote, the more expensive and complex it gets. I opted to go with URC, simply because for their Complete Control based remotes, you can legally get the programming software (depending on where you purchase the remote). I have all of my equipment behind closed doors and use one remote to operate everything. I (finally) made it simple enough that my in-laws (who don't even have cable TV) were able to pick it up and use it. But it took HOURS of programming and testing.
I found is that the remote companies (URC, RTI, Creston, Control4, etc) typically only sell their products to installers. The end-users can typically only get the remotes installed and programmed from the installers. There's a few other companies, like Roomie, that allow for end-user solutions. So far, I haven't found them to be nearly as robust though.
There's also the Harmony line you can consider. I specifically needed something that would work behind closed doors, so that option didn't work for me.
Also, there's one other thing to consider: IR codes. Bryston is great about providing those IR codes to users. Be aware that the software may not come with them. Be sure whatever company's remote you look at will allow you to import IR codes that are not already in the system.
