George used to use his "Truth unit" (sounds like a lie detector machine) direct to amp, but says the addition of a preamp has transformed the sound. In full disclosure, his At-Ma's didn't have enough gain without anyway, but the added Plinius M8 (their lower end but highly regarded pre) was startlingly good (weight, soundstage, everything). On a few occasions I've run the MW TP straight in (for grins or when pre is being updated, etc.), but it loses organic qualities, weight, soundstage depth.
The digital volume control loses bits (and resolution) at the lower end; all do, basically.