I love them and use them on my plate amp to sub cabinet connections now. If I was multi-amping I would definitely use them on the speaker end, just to make sure it never gets screwed up.
As far as the high end amp end, it obviously limits the fancy cables people might want to use that already have spades or bananas, so you'd have to be ready to provide a Speakon to binding post adapter of some sort.
I've used Cardas Patented Binding Posts (CPBP) on my amps and like those a lot too. I learned that from living with the Merlin VSM-MX's for a long time. The CPBP's limit you to using spades, but have definitely spoiled me rotten with their ease of use and durability, as opposed to ones like soft copper Edison Price posts and low mass Eichmann posts.