going from traditional kt88 6550 to kt120 kt150 etc require the amp to be able to deliver the proper biasing current, and of course the rest of the circuitry and componentry (esp. output and power transformers) need to be sized and designed to handle the additional output and bandwidth the bigger stronger tubes are capable of... an amp 'can' run those tubes but it does not mean it takes full and proper advantage of what they are able to do if optimized -- best not to conflate a vs b...